Ceramidase Regulates Synaptic Vesicle Exocytosis and Trafficking
نویسندگان
چکیده
منابع مشابه
Ceramidase regulates synaptic vesicle exocytosis and trafficking.
A screen for Drosophila synaptic dysfunction mutants identified slug-a-bed (slab). The slab gene encodes ceramidase, a central enzyme in sphingolipid metabolism and regulation. Sphingolipids are major constituents of lipid rafts, membrane domains with roles in vesicle trafficking, and signaling pathways. Null slab mutants arrest as fully developed embryos with severely reduced movement. The SLA...
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Active zones are specialized regions of the presynaptic plasma membrane designed for the efficient and repetitive release of neurotransmitter via synaptic vesicle (SV) exocytosis. Piccolo is a high molecular weight component of the active zone that is hypothesized to participate both in active zone formation and the scaffolding of key molecules involved in SV recycling. In this study, we use in...
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2ϩ-mediated regula-appears to be a requisite refractory period of at least tion of PIP 2 metabolism, Hardie et al. estimate that a 20 ms between fusion of one vesicle and the next at a single photon of light might deplete all of the PIP 2 in four single release site (Stevens and Wang, 1995), with a microvilli rather than the PIP 2 in the immediate vicinity of maximum rate of 15–30 fusion events...
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Actin is a regulator of synaptic vesicle mobilization and exocytosis, but little is known about the mechanisms that regulate actin at presynaptic terminals. Genetic data on LIMK1, a negative regulator of actin-depolymerizing proteins of the ADF/cofilin family, suggest a role for ADF/cofilin in presynaptic function. However, synapse physiology is fully preserved upon genetic ablation of ADF in m...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2004
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1146-04.2004